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Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. [4] Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. [4] Digoxin is one of the oldest medications used in the field of cardiology.
Used as a herbal remedy: an aqueous extract of the plant has sedative and anxiolytic actions. [66] Eucalyptus globulus: Eucalyptus: Leaves were widely used in traditional medicine as a febrifuge. [67] Eucalyptus oil is commonly used in over-the-counter cough and cold medications, as well as for an analgesic. [68] Euonymus atropurpureus: Wahoo
Oleandrin is a cardiac glycoside found in the poisonous plant oleander (Nerium oleander L.). [1] As a main phytochemical of oleander, oleandrin is associated with the toxicity of oleander sap, and has similar properties to digoxin.
An unusual side effect of digoxin is a disturbance of color vision (mostly yellow and green) called xanthopsia. Vincent van Gogh's "Yellow Period" may have somehow been influenced by concurrent digitalis therapy. Other oculotoxic effects of digoxin include generalized blurry vision, as well as seeing a "halo" around each point of light.
The use of D. purpurea extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, [24] [25] [26] which is considered the beginning of modern therapeutics. In contemporary medicine, digitalis (usually digoxin) is obtained from D. lanata.
Edgbaston Hall. Born in England, Withering attended Edinburgh Medical School from 1762 to 1766. In 1767 he started as a consultant at Stafford Royal Infirmary. He married Helena Cookes (an amateur botanical illustrator, and a former patient of his) in 1772; they had three children (the first, Helena was born in 1775 but died a few days later, William was born in 1776, and Charlotte in 1778).
Structural formula of the potassium-sparing diuretics. Click to enlarge. Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2]
Digoxin is widely used in the treatment of various heart conditions. A typical protocol to isolate a pure chemical agent from natural origin is bioassay-guided fractionation , meaning step-by-step separation of extracted components based on differences in their physicochemical properties, and assessing the biological activity , followed by next ...