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The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. [ 1 ] [ 2 ] Hereditary APC resistance is usually caused by the factor V Leiden mutation, whereas acquired APC resistance has been linked to antiphospholipid antibodies ...
Activated protein C resistance (APCR) Protein C Anticoagulant Pathway: Thrombin escaping from a site of vascular injury binds to its receptor thrombomodulin (TM) on the intact cell surface. As a result, thrombin loses its procoagulant properties and instead becomes a potent activator of protein C. Activated protein C (APC) functions as a ...
The addition of activated protein C (APC) to a TGA results in an inhibition of thrombin generation as measured by reduction of the endogenous thrombin potential (ETP; area under the thrombin generation curve). [4] This can be used to assess APC resistance and is termed the ETP-based APC resistance test. [4]
ETP-based activated protein C resistance test (ETP-based APCR) Thrombodynamics test. Non-homogenous: realization of the three-dimensional model of the clot growth; Use of platelet free plasma; Record of information about the clot formation as a diagram, giving the possibility to calculate the key parameters of the blood coagulation system
Coagulation activation markers are biomarkers of net activation of coagulation and fibrinolysis. [1] [2] Examples include prothrombin fragment 1+2 (F1+2), thrombin–antithrombin complex (TAT), fibrinopeptide A (FpA), fibrin monomers (FMs), plasmin-α 2-antiplasmin complex (PAP), activated protein C–protein C inhibitor (APC-PCI), and D-dimer (DD).
Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). [1] [2] [3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications. [2] [3] [4] It is a marker of thrombin generation and indicates hypercoagulability.
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