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Dobutamine is administered as a racemic mixture consisting of both (+) and (−) isomers; the (+) isomer is a potent β 1 agonist and α 1 antagonist, while the (−) isomer is an α 1 agonist. [9] The administration of the racemate results in the overall β 1 agonism responsible for its activity.
2,5-Dimethoxy-4-isobutylamphetamine (DOIB or DOiBu) is a serotonin 5-HT 2A receptor agonist, serotonergic psychedelic, and anti-inflammatory drug of the phenethylamine, amphetamine, and DOx families.
2,5-Dimethoxy-4-sec-butylamphetamine (DOSB or DOSBu), also known as 1-(2,5-dimethoxy-4-(2-butyl)phenyl)-2-aminopropane (1-DBPAP), is a serotonin receptor modulator of the phenethylamine, amphetamine, and DOx families.
2C-iBu is a highly potent and robustly efficacious serotonin 5-HT 2A receptor agonist. [4] Its EC 50 Tooltip half-maximal effective concentration values are 1.3 nM for calcium mobilization and 57.5 nM for β-arrestin-2 recruitment, whereas its E max Tooltip maximal efficacy values are 103% for calcium mobilization and 77% for β-arrestin-2 recruitment relative to serotonin. [4]
Bevantolol was a drug candidate for angina and hypertension that acted as both a beta blocker and a calcium channel blocker. [1] [2] It was discovered and developed by Warner-Lambert [3] but in January 1989 the company announced that it had withdrawn the New Drug Application; the company's chairman said: "Who needs the 30th beta blocker?"
βOH-2C-B is a controlled substance in the following countries: Germany: βOH-2C-B is controlled under the New Psychoactive Substances Act (NpSG) as of November 26, 2016.
2C-I, also known as 2,5-dimethoxy-4-iodophenethylamine, is a phenethylamine of the 2C family with psychedelic effects. [1] It was first synthesized by Alexander Shulgin, and is described in Shulgin's book PiHKAL (1991).
Lomevactone (INN; developmental code name DR-250) is a drug described as a psychostimulant and antidepressant which was synthesized and assayed in the 1980s, but was never marketed. [ 1 ] [ 2 ] Stereoisomers