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The following outline is provided as an overview of and topical guide to genetics: . Genetics – science of genes, heredity, and variation in living organisms. [1] [2] Genetics deals with the molecular structure and function of genes, and gene behavior in context of a cell or organism (e.g. dominance and epigenetics), patterns of inheritance from parent to offspring, and gene distribution ...
An example in dog coat genetics is the homozygosity with the allele "e e" on the Extension-locus making it impossible to produce any other pigment than pheomelanin. Although the allele "e" is a recessive allele on the extension-locus itself, the presence of two copies leverages the dominance of other coat colour genes.
Schematic illustration of maternal (mtDNA) gene-flow in and out of Beringia, from 25,000 years ago to present. The genetic history of the Indigenous peoples of the Americas is divided into two distinct periods: the initial peopling of the Americas from about 20,000 to 14,000 years ago (20–14 kya), [1] and European contact, after about 500 years ago.
Molecular genetics is a branch of biology that addresses how differences in the structures or expression of DNA molecules manifests as variation among organisms. Molecular genetics often applies an "investigative approach" to determine the structure and/or function of genes in an organism's genome using genetic screens .
[6] [7] RNase H-dependent oligonucleotides cause the target mRNA molecules to be degraded, while steric-blocker oligonucleotides prevent translation of the mRNA molecule. [ 6 ] [ 7 ] The majority of antisense drugs function through the RNase H-dependent mechanism, in which RNase H hydrolyzes the RNA strand of the DNA/RNA heteroduplex .
Mendelian inheritance (also known as Mendelism) is a type of biological inheritance following the principles originally proposed by Gregor Mendel in 1865 and 1866, re-discovered in 1900 by Hugo de Vries and Carl Correns, and later popularized by William Bateson. [1]
Reverse genetics is a method in molecular genetics that is used to help understand the function(s) of a gene by analysing the phenotypic effects caused by genetically engineering specific nucleic acid sequences within the gene. The process proceeds in the opposite direction to forward genetic screens of classical genetics.
A large gene pool indicates extensive genetic diversity, which is associated with robust populations that can survive bouts of intense selection.Meanwhile, low genetic diversity (see inbreeding and population bottlenecks) can cause reduced biological fitness and an increased chance of extinction, although as explained by genetic drift new genetic variants, that may cause an increase in the ...