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Hyperbilirubinemia is a clinical condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin, a product of erythrocytes breakdown. In severe cases, it is manifested as jaundice , the yellowing of tissues like skin and the sclera when excess bilirubin deposits in them. [ 1 ]
Neonatal hyperbilirubinemia, neonatal icterus, jaundice in newborns: Jaundice in a newborn: Specialty: Pediatrics: Symptoms: Yellowish discoloration of the skin and white part of the eyes [1] Complications: Seizures, cerebral palsy, kernicterus [1] Usual onset: Newborns [1] Types: Physiologic, pathologic [1] Causes
The AAP Red Book, or Report of the Committee on Infectious Diseases of the American Academy of Pediatrics, is a hardcover, softcover, and electronic reference to the "manifestations, etiology, epidemiology, diagnosis, and treatment of some 200 childhood infectious diseases". The Red Book first appeared as an eight-page booklet in 1938. The most ...
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. [3] [6] Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. [7]
The AAP News is the academy's official news magazine, [8] and Pediatrics is its flagship journal. [9] The AAP issues a weekly report [10] on COVID-19 cases in the United States. States began reporting COVID-19 cases on September 17, 2020. The AAP tracked 587,948 child COVID-19 cases, 5,016 child hospitalizations, and 109 child deaths. [11]
Crigler–Najjar syndrome is a rare inherited disorder affecting the metabolism of bilirubin, a chemical formed from the breakdown of the heme in red blood cells. The disorder results in a form of nonhemolytic jaundice, which results in high levels of unconjugated bilirubin and often leads to brain damage in infants.
The syndrome cannot cause severe indirect hyperbilirubinemia in neonates by itself, but it may have a summative effect on rising bilirubin when combined with other factors, [10] for example in the presence of increased red blood cell destruction due to diseases such as G6PD deficiency.
Gestational diabetes increases risk for further maternal and fetal complications such as development of pre-eclampsia, need for cesarean delivery, preterm delivery, polyhydramnios, macrosomia, shoulder dystocia, fetal hypoglycemia, hyperbilirubinemia, and admission into the neonatal intensive care unit.