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A normal human platelet count ranges from 150,000 to 450,000 platelets/microliter (μL) of blood. [4] Values outside this range do not necessarily indicate disease. One common definition of thrombocytopenia requiring emergency treatment is a platelet count below 50,000/μL. [5]
However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [15] and a normal bleeding time does not exclude a platelet disorder. [16] Bone marrow examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt. [12]
Therapeutic plasma exchange (TPE) is a novel treatment for immune-mediated diseases and little research has been done for the effectiveness of TPE and patients with IMT. [15] TPE requires removing the patient's plasma which contains antibodies and replacing it with fluids such as sodium chloride , frozen plasma, packed red blood cells, and ...
The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
In England only 1% of adult platelet components are tested to check the number of platelets meet the minimum required standard of 2.4 x 10 11 platelets. [13] [14] Only components that contain fewer than 1.6 x 10 11 platelets are discarded.
Due to the high mortality of untreated TTP, a presumptive diagnosis of TTP is made even when only microangiopathic hemolytic anemia and thrombocytopenia are seen, and therapy is started. Transfusion is contraindicated in thrombotic TTP, as it fuels the coagulopathy. Since the early 1990s, plasmapheresis has become the treatment of choice for TTP.
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