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The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
Mucosal disruption in acid peptic disease patients can be caused by infection, barrier disruption, or gastric acid hypersecretion.Acid peptic diseases can arise due to various risk factors such as Helicobacter pylori infection, alcoholism, tobacco use, cocaine and amphetamine use, nonsteroidal anti-inflammatory drug use (NSAIDs), fasting, Zollinger-Ellison syndrome, angiogenesis inhibitor ...
Aspirin "weakens the stomach's protective lining against stomach acid, making the stomach and intestines more vulnerable to ulcers, which can bleed," according to Harvard Health.
Treatment includes stopping smoking, stopping use of NSAIDs, stopping alcohol, and taking medications to decrease stomach acid. [1] The medication used to decrease acid is usually either a proton pump inhibitor (PPI) or an H2 blocker, with four weeks of treatment initially recommended. [1]
As a result, the stomach's secretion of essential substances such as hydrochloric acid, pepsin, and intrinsic factor is impaired, leading to digestive problems. The most common are pernicious anemia possibly leading to vitamin B 12 deficiency; and malabsorption of iron, leading to iron deficiency anaemia. [2]
The use of acid suppression therapy is a common response to GERD symptoms and many people get more of this kind of treatment than their case merits. [50] [57] [58] [52] [51] [59] The overuse of acid suppression is a problem because of the side effects and costs. [50] [58] [52] [51] [59]
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