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Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae , including henbane , mandrake , angel's trumpets , jimsonweed , the sorcerers' tree , and Atropa belladonna (deadly nightshade).
[17] [18] One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia. [ 19 ] Memantine has been associated with a modest improvement; [ 20 ] with small positive effects on cognition , mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimer's disease.
Scopolamine has been used to model the defects in cholinergic function for models of Alzheimer's, dementia, fragile X syndrome, and Down syndrome. [76] [81] [82] [83] Scopolamine has been identified as a psychoplastogen, which refers to a compound capable of promoting rapid and sustained neuroplasticity in a single dose. [84]
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Dementia prevention is a critical area of research, as experts want to understand what people can do to decrease dementia risk. A recent study found that more than 5 years of taking medications ...
Steigmann and Kaminski [11] examined the antisecretory effect of 0.1296 mg belladonna alkaloids + 16.2 mg phenobarbital (Donnatal®) in peptic ulcer patients, motility in a subgroup of patients and clinical effects in all patients (N =176). Of the IBS patients (n =66), a reported good response with complete relief was found in 53% of male ...
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