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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
Plants grown as industrial crops are the source of a wide range of products used in manufacturing, sometimes so intensively as to risk harm to the environment. [17] Nonfood products include essential oils, natural dyes, pigments, waxes, resins, tannins, alkaloids, amber and cork.
Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
Human impact on the environment (or anthropogenic environmental impact) refers to changes to biophysical environments [1] and to ecosystems, biodiversity, and natural resources [2] caused directly or indirectly by humans. Modifying the environment to fit the needs of society (as in the built environment) is causing severe effects [3] [4 ...
Human interactions with fungi include both beneficial uses, whether practical or symbolic, and harmful interactions such as when fungi damage crops, timber, food, or are pathogenic to animals. Yeasts have been used since ancient times to leaven bread and to ferment beer and wine .
Non-human animals, and products made from them, are used to assist in hunting. Humans have used hunting dogs to help chase down animals such as deer, wolves, and foxes; [36] birds of prey from eagles to small falcons are used in falconry, hunting birds or mammals; [37] and tethered cormorants have been used to catch fish. [38]
Prominent computer scientist Fei-Fei Li is building a startup that uses human-like processing of visual data to make artificial intelligence (AI) capable of advanced reasoning, six sources told ...
The word pesticide derives from the Latin pestis (plague) and caedere (kill). [5]The Food and Agriculture Organization (FAO) has defined pesticide as: . any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the ...