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Eosinophils are also involved in many other biological processes, ... But, perhaps the most common cause for eosinophilia is an allergic condition such as asthma.
Eosinophilia and comparatively fewer cases of hypereosinophilia are associated with the following known diseases that are known or thought to have an allergic basis: allergic rhinitis, asthma, atopic dermatitis, eosinophilic esophagitis, chronic sinusitis, aspirin-exacerbated respiratory disease, allergic bronchopulmonary aspergillosis, chronic ...
The cells involved in allergic responses, such as eosinophils, are predominantly expressed through eotaxin and the CCR-3 receptor. [2] The binding of eotaxin and the other related chemokines to the CCR-3 receptor is seen to play a major role in eosinophil recruitment in allergic inflammation. [5] We can find the highest levels of eotaxin in the ...
A type IV hypersensitivity reaction is mediated by T cells that provoke an inflammatory reaction against exogenous or endogenous antigens. In certain situations, other cells, such as monocytes, eosinophils, and neutrophils, can be involved. After antigen exposure, an initial local immune and inflammatory response occurs that attracts leukocytes.
Eosinophils are also the predominant inflammatory cells in allergic reactions. The most important causes of eosinophilia include allergies such as asthma, hay fever, and hives; and parasitic infections. They secrete chemicals that destroy large parasites, such as hookworms and tapeworms, that are too big for any one white blood cell to phagocytize.
In the laboratory tests, the doctor will take a nasal smear and it will be examined microscopically for factors that may indicate a cause: increased numbers of eosinophils (white blood cells), which indicates an allergic condition. If there is a high count of eosinophils, an allergic condition might be present. [27]
FcεRI is the Fc receptor on granulocytes, that is involved in allergic reactions and defense against parasitic infections. When an appropriate allergic antigen or parasite is present, the cross-linking of at least two IgE molecules and their Fc receptors on the surface of a granulocyte will trigger the cell to rapidly release preformed ...
IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils. Fc receptors are also found on eosinophils, monocytes, macrophages and platelets in humans. There are two types of Fcε receptors: [citation needed] FcεRI (type I Fcε receptor), the high-affinity IgE receptor