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Inhibition of adult neurogenesis in the hippocampus has been shown to have various effects on learning and memory, conditioning, and investigative behaviors. Impaired fear conditioning has been seen in studies involving rats with a lack of adult neurogenesis in the hippocampus. [58]
The main function of the SGZ is to carry out hippocampal neurogenesis, the process by which new neurons are bred and functionally integrated into the granular cell layer of the dentate gyrus. Contrary to long-standing beliefs, neurogenesis in the SGZ occurs not only during prenatal development but throughout adult life in most mammals ...
A study showed that a low dose (0.1 mg/kg) of psilocybin given to mice increased neurogenesis in the hippocampus 2 weeks after administration, while a high dose (1 mg/kg) significantly decreased neurogenesis. [32] No orally-available drugs are known to elicit neurogenesis outside of the already neurogenic niches.
Peter Eriksson (June 5, 1959 – August 2, 2007) [1] was a Swedish stem cell neuroscientist.. Eriksson was a frequently cited scientist who conducted ground-breaking research on neurogenesis in the hippocampus of the adult human brain.
Adult neurogenesis is the process by which functional, mature neurons are produced from neural stem cells (NSCs) in the adult brain. In most mammals, including humans, it only occurs in the subgranular zone of the hippocampus , and in the olfactory bulb . [ 1 ]
Adult neurogenesis is characterized by neural stem cell differentiation and integration in the mature adult mammalian brain. This process occurs in the dentate gyrus of the hippocampus and in the subventricular zones of the adult mammalian brain.
However, the SVZ of the ventral telencephalon persists throughout life. The adult SVZ is composed of four distinct layers [5] of variable thickness and cell density as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian ...
Adult neurogenesis [ edit ] The olfactory bulb is, along with both the subventricular zone and the subgranular zone of the dentate gyrus of the hippocampus, one of only three structures in the brain observed to undergo continuing neurogenesis in adult mammals.