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Because of its relatively long elimination half-life (10–12 hours), doxylamine is associated with next-day effects including sedation, drowsiness, grogginess, dry mouth, and tiredness when used as a hypnotic. [26] [18] This may be described as a "hangover effect". [18]
1.5 ZzzQuil. 1.6 Children's NyQuil. 1.7 Reformulation. 2 References. 3 External links. Toggle the table of contents. ... This page was last edited on 7 January 2025, ...
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
A study in 2000 found that long-term benzodiazepine therapy does not result in brain abnormalities. [75] Withdrawal from high-dose use of nitrazepam anecdotally was alleged in 2001 to have caused severe shock of the whole brain with diffuse slow activity on EEG in one patient after 25 years of use. After withdrawal, abnormalities in hypofrontal ...
A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...
How Long Do You Think It's Gonna Last? is the second studio album by American indie duo Big Red Machine, which consists of musicians Aaron Dessner and Justin Vernon. It was released on August 27, 2021, via 37d03d and Jagjaguwar record labels. Dessner stated the album is built around themes of childhood, familial dynamics, and mental health.