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Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
It is a weaker laxative than bisacodyl and castor oil. [1] Common side effects of senna glycoside include abdominal cramps. [3] It is not recommended for long-term use, as it may result in poor bowel function or electrolyte problems. [1] While no harm has been found to result from use while breastfeeding, such use is not typically recommended. [1]
Methylscopolamine or methscopolamine, usually provided as the bromide or nitrate salt, is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion. [1]
Sodium picosulfate is a prodrug. [5] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridyl)methane (DPM, BHPM).
The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access website, acting as a portal to information on the biological targets of licensed drugs and other small molecules. The Guide to PHARMACOLOGY (with GtoPdb being the standard abbreviation) is developed as a joint venture between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).
Sodium citrate saline is one of the most effective osmotic laxatives (secondary in action only to magnesium citrate). [8] Its laxative action is the result of osmotic imbalance that extracts bound water from stool and pulls it back into the large bowel.
Oxyphenisatine (or oxyphenisatin) is a laxative. [3] It is closely related to bisacodyl, sodium picosulfate, and phenolphthalein.Long-term use is associated with liver damage, [4] and as a result, it was withdrawn in most countries in the early 1970s.
Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...