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  2. Glomerular filtration rate - Wikipedia

    en.wikipedia.org/wiki/Glomerular_filtration_rate

    Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [4] Central to the physiologic maintenance of GFR is the differential basal tone of the afferent (input) and efferent (output) arterioles (see diagram).

  3. Glomerulus (kidney) - Wikipedia

    en.wikipedia.org/wiki/Glomerulus_(kidney)

    Renal corpuscle showing glomerulus and glomerular capillaries Figure 2: (a) Diagram of the juxtaglomerular apparatus: it has specialized cells working as a unit which monitor the sodiujuxtaglomerular apparatus: it has three types of specm content of the fluid in the distal convoluted tubule (not labelled - it is the tubule on the left) and adjust the glomerular filtration rate and the rate of ...

  4. Assessment of kidney function - Wikipedia

    en.wikipedia.org/wiki/Assessment_of_kidney_function

    The glomerular filtration rate (GFR) describes the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [3] Creatinine clearance (C Cr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.

  5. Tubuloglomerular feedback - Wikipedia

    en.wikipedia.org/wiki/Tubuloglomerular_feedback

    Tubuloglomerular feedback is one of several mechanisms the kidney uses to regulate glomerular filtration rate (GFR). It involves the concept of purinergic signaling, in which an increased distal tubular sodium chloride concentration causes a basolateral release of adenosine from the macula densa cells. This initiates a cascade of events that ...

  6. Renal physiology - Wikipedia

    en.wikipedia.org/wiki/Renal_physiology

    This is performed at the microscopic level by many hundreds of thousands of filtration units called renal corpuscles, each of which is composed of a glomerulus and a Bowman's capsule. A global assessment of renal function is often ascertained by estimating the rate of filtration, called the glomerular filtration rate (GFR).

  7. Diabetic nephropathy - Wikipedia

    en.wikipedia.org/wiki/Diabetic_nephropathy

    Another possible mechanism is that abnormal vascular control in diabetic nephropathy leads to a reduction in afferent glomerular arteriolar resistance and an increase in efferent glomerular arteriolar resistance, leading to a net increase in renal blood flow (RBF) and glomerular filtration rate (GFR). [23] Glomerular hyperfiltration and an ...

  8. Kidney - Wikipedia

    en.wikipedia.org/wiki/Kidney

    Dialysis may be instituted when approximately 85%–90% of kidney function is lost, as indicated by a glomerular filtration rate (GFR) of less than 15. Dialysis removes metabolic waste products as well as excess water and sodium (thereby contributing to regulating blood pressure); and maintains many chemical levels within the body.

  9. Intraglomerular mesangial cell - Wikipedia

    en.wikipedia.org/wiki/Intraglomerular_mesangial_cell

    There are five known functions of intraglomerular mesangial cells: structural support of glomerular capillaries, regulation of the glomerular filtration rate, mesangial matrix formation, phagocytosis, and monitoring of capillary lumen glucose concentration [citation needed]. Intraglomerular mesangial cells have contractile activity.