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] NMS was first described in 1960 by French clinicians who had been working on a study involving haloperidol. They characterized the condition that was associated with the side effects of haloperidol " syndrome malin des neuroleptiques ", which was translated to neuroleptic malignant syndrome.
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
In the management of Parkinson's disease, due to the chronic nature of Parkinson's disease (PD), a broad-based program is needed that includes patient and family education, support-group services, general wellness maintenance, exercise, and nutrition. At present, no cure for the disease is known, but medications or surgery can provide relief ...
Haldol (haloperidol) – typical ... – an antipsychotic used to treat hallucinations and delusions caused by psychosis related to Parkinson's disease; P ...
The first LAI antipsychotics (often referred to as simply "LAIs") were the typical antipsychotics fluphenazine and haloperidol. [18] Both fluphenazile and haloperidol are formulated as decanoates, referring to the attachment of a decanoic acid group to the antipsychotic molecule. [18] These are then dissolved in an organic oil. [18]
Tardive dyskinesia appears to be more frequent with high-potency first-generation antipsychotics, such as haloperidol, and tends to appear after chronic and not acute treatment. It is characterized by slow (hence the tardive ) repetitive, involuntary and purposeless movements, most often of the face, lips, legs, or torso, which tend to resist ...
Although Parkinson's disease is primarily a disease of the nigrostriatal pathway and not the extrapyramidal system, loss of dopaminergic neurons in the substantia nigra leads to dysregulation of the extrapyramidal system. Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's.
Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia. [2] [3] [4