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Cerebral atrophy can be hard to distinguish from hydrocephalus because both cerebral atrophy and hydrocephalus involve an increase in cerebrospinal fluid (CSF) volume. In cerebral atrophy, this increase in CSF volume comes as a result of the decrease in cortical volume. In hydrocephalus, the increase in volume happens due to the CSF itself. [20]
White matter hyperintensities can be caused by a variety of factors, including ischemia, micro-hemorrhages, gliosis, damage to small blood vessel walls, breaches of the barrier between the cerebrospinal fluid and the brain, or loss and deformation of the myelin sheath.
The volume and frequency is strongly associated with increasing age. [2] They are also seen in a number of neurological disorders and psychiatric illnesses . For example, deep white matter hyperintensities are 2.5 to 3 times more likely to occur in bipolar disorder and major depressive disorder than control subjects.
Hydrocephalus ex vacuo is a condition in which there is ventriculomegaly due to loss of brain volume which then results in a subsequent increase in CSF. [19] This is most commonly seen in patients with neurodegenerative disorders such as Alzheimer's disease (due to hippocampal atrophy specifically). [ 20 ]
The supratentorial region contains the cerebrum, while the infratentorial region contains the cerebellum. Although the Roman era anatomist Galen commented upon it, the functional significance of this neuroanatomical division was first described using ‘modern’ terminology by John Hughlings Jackson , founding editor of the medical journal Brain .
Perisylvian syndrome is a rare neurological disease characterized by damage to the sylvian fissure (lateral sulcus), an area in the brain involved in language and speech. . The main symptoms are difficulty chewing and swallowing, low muscle tone in the face and tongue, speech and language development disorders, and epile
Clinically subcortical dementia usually is seen with features like slowness of mental processing, forgetfulness, impaired cognition, lack of initiative-apathy, depressive symptoms (such as anhedonia, negative thoughts, loss of self-esteem and dysphoria), loss of social skills along with extrapyramidal features like tremors and abnormal movements.
Diet and lifestyle modification (e.g. low-protein diet in diabetic nephropathy, smoking cessation, weight loss, improved nutrition, and regular exercise). [16] [25] [26] Intensive management of coexisting conditions and risk factors (e.g. adequate control of blood pressure, diabetes and related metabolic abnormalities and lipid management). [25 ...