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The basal ganglia are of major importance for normal brain function and behaviour. Their dysfunction results in a wide range of neurological conditions including disorders of behaviour control and movement, as well as cognitive deficits that are similar to those that result from damage to the prefrontal cortex . [ 11 ]
The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
The basal ganglia are located bilaterally, and have rostral and caudal divisions. The putamen is located in the rostral division as part of the striatum. The basal ganglia receive input from the cerebral cortex, via the striatum. This is a transverse section of the striatum from a structural MR image.
The caudate nucleus is one of the structures that make up the corpus striatum, which is part of the basal ganglia in the human brain. [1] Although the caudate nucleus has long been associated with motor processes because of its role in Parkinson's disease, [2] [clarification needed] [3] it also plays important roles in nonmotor functions, such as procedural learning, [4] associative learning ...
The basal ganglia are the central site at which decisions are made: the basal ganglia exert a sustained inhibitory control over most of the motor systems in the brain; when this inhibition is released, a motor system is permitted to execute the action it is programmed to carry out.
Anatomical overview of the main circuits of the basal ganglia. Subthalamic nucleus is shown in red. Picture shows 2 coronal slices that have been superimposed to include the involved basal ganglia structures. + and - signs at the point of the arrows indicate respectively whether the pathway is excitatory or inhibitory in effect.
Part of the human brain, the basal forebrain structures are located in the forebrain to the front of and below the striatum. They include the ventral basal ganglia (including nucleus accumbens and ventral pallidum ), nucleus basalis , diagonal band of Broca , substantia innominata , and the medial septal nucleus .
The basal ganglia form a major brain system in all vertebrates, but in primates (including humans) there are special differentiating features. The basal ganglia include the striatum , globus pallidus , substantia nigra and subthalamic nucleus .