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Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called trephine biopsy) and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia , multiple myeloma , lymphoma , anemia , and pancytopenia .
A Wright's-stained bone marrow aspirate smear from a patient with leukemia. Bone marrow examination is the pathologic analysis of samples of bone marrow obtained via biopsy and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, anemia, and pancytopenia.
Dysplasia can affect all three lineages seen in the bone marrow. The best way to diagnose dysplasia is by morphology and special stains used on the bone marrow aspirate and peripheral blood smear. Dysplasia in the myeloid series is defined by: Granulocytic series [citation needed]:
Bone marrow aspirate: ring sideroblasts. Ringed sideroblasts are seen in the bone marrow. On the peripheral blood smear can be found erythrocytes with basophilic stippling (cytoplasmic granules of RNA precipitates) and Pappenheimer bodies (cytoplasmic granules of iron). [13] The anemia is moderate to severe and dimorphic.
Romanowsky-type stains are widely used in the examination of blood, in the form of blood films, and in the microscopic examination of bone marrow biopsies and aspirate smears. [1] [23] Examination of both blood and bone marrow can be of importance in the diagnosis of a variety of blood diseases.
Histopathological image representing a bone marrow aspirate in a patient with essential thrombocythemia. Specialty: Hematology Symptoms: Fatigue, insomnia, migraines, headache, and dizziness. [1] Complications: Thrombosis, transient ischemic attack, acute coronary syndrome, Budd-Chiari syndrome. [1] Causes
Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B 12 (or B 12 binding capacity), serum urate [7] or direct ...
A definitive diagnosis requires a bone marrow aspiration and biopsy. [18] Bone marrow is examined under light microscopy, as well as flow cytometry, to diagnose the presence of leukemia, to differentiate AML from other types of leukemia (e.g. acute lymphoblastic leukemia), and to provide information about how mature or immature the affected ...