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  2. Treatment-resistant depression - Wikipedia

    en.wikipedia.org/wiki/Treatment-resistant_depression

    Ketamine has been tested as a rapid-acting antidepressant [22] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [23] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [24] [25]

  3. List of investigational antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_investigational...

    This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among others.

  4. Endogenous depression - Wikipedia

    en.wikipedia.org/wiki/Endogenous_depression

    Endogenous depression is an atypical subclass of major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [ 1 ] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [ 2 ]

  5. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

    www.aol.com/switching-antidepressants-safety...

    Research shows that approximately one-third of people with depression have treatment-resistant depression (TRD). With TRD, depression doesn’t always improve through standard treatments, like ...

  6. NV-5138 - Wikipedia

    en.wikipedia.org/wiki/NV-5138

    NV-5138 has been found to increase mTORC1 signaling within physiologic range and to stimulate synaptogenesis in the mPFC, and further to induce rapid antidepressant effects in multiple animal models of depression. [1] [4] Like those of ketamine, these actions were demonstrated to require the signaling of brain-derived neurotrophic factor (BDNF ...

  7. List of antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_antidepressants

    This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.

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