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[58] [123] A decrease of hemoglobin levels of 1 to 2 g/dL after about 6 months of treatment may be observed. [127] Greater decreases in hemoglobin levels and anemia incidences have been reported with flutamide relative to bicalutamide (e.g., 9.8% anemia rate with flutamide plus a GnRH agonist).
The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
On average, exposures at 100 ppm or greater is dangerous to human health. [23] The WHO recommended levels of indoor CO exposure in 24 hours is 4 mg/m 3 . [ 24 ] Acute exposure should not exceed 10 mg/m 3 in 8 hours, 35 mg/m 3 in one hour and 100 mg/m 3 in 15 minutes.
After sitting for several years, the radioactivity reduces to a level where extraction of the long-lived isotopes, including technetium-99, becomes feasible. A series of chemical processes yields technetium-99 metal of high purity. [84]