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Brimonidine is an α 2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. [4] [5] In rosacea it improves the redness. [5] It is used as eye drops or applied to the skin. [4] [5] It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate. [6]
Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist ) and timolol (a β adrenergic blocker ).
[3] [5] As eye drops it is used to treat increased pressure inside the eye such as in ocular hypertension and glaucoma. [3] By mouth it is used for high blood pressure, chest pain due to insufficient blood flow to the heart, to prevent further complications after a heart attack, and to prevent migraines. [5] Common side effects with the drops ...
Alcon's (ALC) new preservative-free solution for patients with dry eye symptoms is the latest addition to its leading global artificial tear brand Systane.
Upon the original patent expiration, Hi-Tech Pharma was the first of many generic competitors to submit an abbreviated new drug application (ANDA) for dorzolamide hydrochloride/timolol maleate eye drops. [19] Hi-Tech Pharma's ANDA was approved on 28 October 2008. At the time, controversy surrounded the approval of this first ANDA.
Preservative-free artificial formulations are indicated for patients who cannot tolerate artificial tear formulations with preservatives, patients who are using artificial tears more than four to six times a day, [10] and patients who are using multiple topical eye drops with preservatives. [9] Preservative-free eye drops are found in single vials.