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The COVID-19 mRNA vaccines from Moderna and Pfizer–BioNTech had short-term efficacy rates of over 90 percent against the original SARS-CoV-2 virus. Prior to mRNA, drug trials on pathogens other than COVID-19 were not effective and had to be abandoned in the early phases of trials. The reason for the efficacy of the new mRNA vaccines is not clear.
Each dose contains 50 μg of mRNA. Moderna’s unnamed version of the vaccine for children 6 months to 11 years has been authorized for emergency use. ... No vaccine is 100% effective—especially ...
An mRNA vaccine (or RNA vaccine) is a novel type of vaccine which is composed of the nucleic acid RNA, packaged within a vector such as lipid nanoparticles. [69] Among the COVID-19 vaccines are a number of RNA vaccines to combat the COVID-19 pandemic and some have been approved or have received emergency use authorization in some countries.
The mRNA vaccines were developed and approved for use at unprecedented speed, and demonstrated over 90% efficacy. In addition to vaccines for infectious diseases, mRNA has potential applications in treatment of cancer, cardiovascular and metabolic diseases [59] [60] [61] including ischemia. [62]
Vaccine efficacy differs from vaccine effectiveness in the same way that an explanatory clinical trial differs from an intention-to-treat trial [clarification needed]: vaccine efficacy shows how effective a vaccine could be given ideal circumstances and 100% vaccine uptake (such as the conditions within a controlled clinical trial); vaccine effectiveness measures how well a vaccine performs ...
A study among pre-surgical patients across the Mayo Clinic system in the United States, showed that mRNA vaccines were 80% protective against asymptomatic infections. [420] A UK study found that a single dose of the Oxford–AstraZeneca COVID-19 vaccine is about 73% (27 – 90%) effective in people aged 70 and older. [421]
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