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It consists mainly of lymphocytes, T cell and B cell enriched zones, follicle-associated epithelium (FAE) with epithelial M cells and some erythrocytes. M cells are typical for antigen intake from mucosa. In some areas of NALT, there are lymphatic vessels and HEVs (high endothelial venule). Dendritic cells and macrophages are also present.
Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
The epithelium, the most exposed part of the mucosa, is a glandular epithelium with many goblet cells. Goblet cells secrete mucus , which lubricates the passage of food along and protects the intestinal wall from digestive enzymes.
CD58, lymphocyte-function antigen 3 (LFA-3), is a glycoprotein that plays a vital role in the body's immune response.The natural ligand to CD58, CD2, is most commonly found on the surfaces of both T cells and Natural Killer cells (T/NK cells). [3]
The other cell types are the secretory cells – goblet cells, Paneth cells, enteroendocrine cells, and Tuft cells. Paneth cells are absent in the colon. [1] [2] As part of its protective role, the intestinal epithelium forms an important component of the intestinal mucosal barrier. Certain diseases and conditions are caused by functional ...
The process of formation begins when the T-cell receptor binds to the peptide:MHC complex on the antigen-presenting cell and initiates signaling activation through formation of microclusters/lipid rafts. Specific signaling pathways lead to polarization of the T-cell by orienting its centrosome toward the site of the immunological synapse. The ...
Mucous cells of the stomach lining secrete mucus (pink) into the lumen. Mucus (/ ˈ m j uː k ə s /, MEW-kəs) is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells.
Unlike their neighbor cells, M cells have the unique ability to take up antigen from the lumen of the small intestine via endocytosis, phagocytosis, or transcytosis. Antigens are delivered to antigen-presenting cells, such as dendritic cells, and B lymphocytes. M cells express the protease cathepsin E, similar to other antigen-presenting cells ...