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Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of several bacterial infections. [10] This includes middle ear infections , strep throat , pneumonia , traveler's diarrhea , and certain other intestinal infections . [ 10 ]
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In December 2020, the chief investigators announced that they had found no benefit from azithromycin in patients hospitalised with COVID-19. 2582 patients had received azithromycin, and 5182 were randomised to usual care alone. 28-day mortality in both cohorts was 19%. [13] These preliminary results were released as a preprint on the same day.
Azithromycin stands apart from other macrolide antibiotics because it is a weak inhibitor of CYP3A4, and does not significantly increase AUC value of co-administered drugs. [ 32 ] The difference in CYP3A4 inhibition by macrolides has clinical implications, for example, for patients who take statins , which are cholesterol-lowering drugs that ...
Generally, antibiotics (like azithromycin [150]) are not effective against viruses, only some bacteria. [152] Azithromycin is sometimes given to patients hospitalized with COVID-19, but only to treat bacterial co-infection. Overuse of azithromycin causes antibiotic resistance, and rare side effects include heart arrhythmias and hearing loss ...
There was preliminary evidence that combining hydroxychloroquine and azithromycin for treating non-hospitalized ("outpatient") people with COVID-19 infection with multiple comorbidities was effective, [67] but this evidence was not confirmed by later studies: co-administration of chloroquine or hydroxychloroquine with azithromycin has been ...
Studies have suggested that azithromycin or ciprofloxacin, may be the most effective antibiotics when treating Enteroaggregative E.coli (EAEC) infections. If either antibiotic isn't effective after 24 hours, a 3-day course of rifaximin is recommended.
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