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This area produces Purkinje cells and deep cerebellar nuclear neurons. These cells are the primary output neurons of the cerebellar cortex and cerebellum. The second germinal zone (cellular birthplace) is known as the rhombic lip, neurons then move by human embryonic week 27 to the external granular layer. This layer of cells—found on the ...
Its lobes are linked through a circuit of neurons connecting to the vermis, the medial structure in the cerebellum. Extensions leave the base of the follucular's lobes which then connect to the spinal cord. The cerebellum, which houses the flocculus, is located in the back and at the base of the human brain, directly above the brainstem. [7]
The first cells generated from the cerebellar primordium form a cap over a diamond-shaped cavity of the developing brain called the fourth ventricle forming the two cerebellar hemispheres. The Purkinje cells that develop later are those of the cerebellum's center-lying section called the vermis.
Cerebellar peduncles. ... Major dopaminergic pathways from dopaminergic cell groups. Mesocortical pathway; ... "Brain Anatomy and How the Brain Works".
A standard test of cerebellar function is to reach with the tip of the finger for a target at arm's length: A healthy person will move the fingertip in a rapid straight trajectory, whereas a person with cerebellar damage will reach slowly and erratically, with many mid-course corrections. Deficits in non-motor functions are more difficult to ...
Purkinje cells of flocculonodular lobe → juxtarestiform body of inferior cerebellar peduncle → vestibular nuclei (synapse/termination of cerebellovestibular fibers) → Medial and lateral vestibulospinal tracts (extrapyramidal upper motor neurons) → (synapse) lower motor neurons → skeletal muscle
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial , globose , emboliform , and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus .
Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell.