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Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying).
Domperidone is a peripherally selective dopamine D 2 receptor antagonist used as an antiemetic, gastroprokinetic agent and galactagogue. Bromopride binds enteric D 2 receptors [ 28 ] and also treats gastroparesis .
Deudomperidone (developmental code name CIN-102; also known as deuterated domperidone) is a dopamine antagonist medication which is under development in the United States for the treatment of gastroparesis. [1] [2] [3] It acts as a selective dopamine D 2 and D 3 receptor antagonist and has peripheral selectivity.
5-HT 3 antagonists are most effective in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV), especially that caused by highly emetogenic drugs such as cisplatin; when used for this purpose, they may be given alone or, more frequently, with a glucocorticoid, usually dexamethasone.
Domperidone; Metoclopramide; Risperidone; Paliperidone; Anti-adrenergics: See also alpha blocker and beta blocker. Clonidine (α-receptor agonist, α 2 > α 1, giving negative feedback) Methyldopa (α 2 agonist, giving negative feedback) Propranolol (β-receptor antagonist) Metoprolol (β-receptor antagonist) Atenolol (β 1 antagonist) Prazosin ...
Dopamine, sold under the brand name Intropin among others, is a medication most commonly used in the treatment of very low blood pressure, a slow heart rate that is causing symptoms, and, if epinephrine is not available, cardiac arrest. [4] In newborn babies it continues to be the preferred treatment for very low blood pressure. [5]
Domperidone (like metoclopramide, a D 2 receptor antagonist) is not approved for enhanced lactation in the USA. [11] [12] By contrast, Australian guidelines consider domperidone to be the preferred galactagogue when non-pharmacological approaches have proved insufficient. [7]
These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [ 2 ] Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by ...