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Lysine Residue 133 serves as the nucleophile and attacks the carbonyl group of 2-Keto-3-deoxy-6-phosphogluconate to form a protonated carbinolamine intermediate, also known as a Schiff base intermediate. [7] [9] [10] The intermediate is stabilized by hydrogen bonding with residues in the active site. [9]
Uses the unique enzymes 6-phosphogluconate dehydratase and 2-keto-deoxy-6-phosphogluconate (KDPG) aldolase and other common metabolic enzymes to other metabolic pathways to catabolize glucose to pyruvate. [1] In the process of breaking down glucose, a net yield of 1 ATP is formed per every one glucose molecule processed, as well as 1 NADH and 1 ...
The KDPG-aldolase RNA motif is a conserved RNA structure that was ... are annotated as encoding aldolases of 2-keto-3-deoxy-6-phosphogluconate or 2-keto-4 ...
2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase The enzyme phosphogluconate dehydratase ( EC 4.2.1.12 ) catalyzes the chemical reaction 6-phospho- D -gluconate ⇌ {\displaystyle \rightleftharpoons } 2-dehydro-3-deoxy-6-phospho- D -gluconate + H 2 O
In those microorganisms which host the Entner-Doudoroff pathway, 6-phosphogluconic acid may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate. v t
The systematic name of this enzyme class is ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 2-keto-3-deoxygluconokinase , 2-keto-3-deoxy-D-gluconic acid kinase , 2-keto-3-deoxygluconokinase (phosphorylating) , 2-keto-3-deoxygluconate kinase , and ketodeoxygluconokinase .
Without pyruvate kinase, A. baylyi can produces pyruvate from the cleavage of 2-keto-3-deoxy-6-phosphogluconate. Additional pyruvate is produced from the enzymatic conversion of phosphoenolpyruvate to oxalacetate, then malate, and then pyruvate. [27]
Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NADP +, whereas its 3 products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate, NADPH, and H +. This enzyme belongs to the family of oxidoreductases , specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor.