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Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of several bacterial infections. [10] This includes middle ear infections , strep throat , pneumonia , traveler's diarrhea , and certain other intestinal infections . [ 10 ]
By inhibiting CYP3A4, macrolide antibitiotics, such as erythromycin and clarithromycin, but not azithromycin, can significantly increase the AUC of the drugs that depend on it for clearance, which can lead to higher risk of adverse effects or drug-drug interactions. Azithromycin stands apart from other macrolide antibiotics because it is a weak ...
John Marshall used to enjoy running but after a serious reaction to antibiotics in 2017 he was left barely able to walk. The 51-year-old from Kirkcaldy says his health changed dramatically after ...
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Effective for gram-positive, gram-negative, anaerobic, and against multi-antibiotic resistant bacteria (such as Staphylococcus aureus [MRSA] and Acinetobacter baumannii), but not effective for Pseudomonas spp. and Proteus spp. Teeth discoloration and same side effects as tetracycline. Not to be given to children and pregnant or lactating women.
Azalides have several advantages over erythromycin such as more potent gram negative antimicrobial activity, acid stability, and side effect tolerability. [3] Although there are few drug interactions with azithromycin, it weakly inhibits the CYP3A4 enzyme. [2]
An overgrowth of drug-resistant microorganisms can lead to a secondary infection such as Clostridioides difficile ("C. diff") or candidiasis ("thrush"). [3] This side-effect is more likely with the use of broad-spectrum antibiotics, given their greater potential to disrupt a larger variety of normal human flora. [7]
Without a new antibiotic weapon, curing highly drug-resistant strains of gonorrhea could require intensive treatment with multiple antibiotics, according to Dr. Jeanne Marrazzo, director of the ...
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