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Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
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Smartwatches are a hot-ticket gift over the holidays, but a new study might have you rethink how you strap the device to your wrist in the future.
They may live thousands of miles apart but Sheryl Lee Ralph and husband Vincent Hughes have been on the same page for decades.. The Abbott Elementary star, 69, opens up to PEOPLE in this week's ...
It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC. This is an example of a PK/PD model , which combines pharmacokinetics and pharmacodynamics .
WASHINGTON (Reuters) -The U.S. House Ethics Committee has voted to release its report on former Representative Matt Gaetz, a source familiar with the committee said on Wednesday, weeks after the ...
The biosynthesis of Taxol is illustrated in more detail in the figure, with steps 1-7 all occurring in the enzyme taxadiene synthase (TS on the figure). Taxol's biosynthesis begins with E,E,E-GGPP losing pyrophosphate via an SN1 mechanism (step 1 in the figure). The double-bond attacks the cation via electrophilic addition, yielding a tertiary ...