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Jacqueline N. Crawley (née Lerner) is an American behavioral neuroscientist and an expert on rodent behavioral analysis. [1] Since July 2012, she is the Robert E. Chason Chair in Translational Research in the MIND Institute and professor of psychiatry and behavioral sciences at the University of California, Davis School of Medicine in Sacramento. [2]
To probe insular neural circuits, Gogolla and her lab use in vivo two-photon calcium imaging to record neural activity while mice are processing emotionally relevant stimuli, and they further use innovative behavioral assays, optogenetic techniques, and machine learning algorithms to link neural activity to behavior, manipulate neural circuits ...
More recent research has used the house mouse (Mus musculus) to model autism because it is a social species. Other strains of mice used include mu opioid receptor knockout mice, as well as Fmr1 knockout mice; the latter are also used as animal models of Fragile X syndrome. [4]
However, because of the multigene involvement in autism, the MECP2 gene has only been identified as a vulnerability factor in autism. [63] The most current model illustrating MECP2 is known as the transcriptional activator model. Another potential molecular convergence involves the early growth response gene-2 (EGR2). [60]
Research using an animal model of obsessive-compulsive disorder employed a standardized paradigm where the behavior of rats in a large open field was video recorded for 55 min on each test. Rat Macroscopic Video Obsessive-compulsive disorder No [2] Allen Brain Atlas: Atlas, stained sections from brains showing development and gene expression
At Stanford, Pașca teaches neural development and principles of drug discovery in neuroscience. Pașca is also the co-director of the CSHL Workshop on autism spectrum disorders. [38] In 2022, he gave a TED talk [39] at the Vancouver event describing the potential of human cellular models to understand disease.
The IACC Strategic Plan was designed to detail research opportunities centered on the six most pressing questions facing those affected by autism and links them to specific research efforts. In 2009, the plan was finalized and submitted to the Secretary of the Department of Health and Human Services; a seventh question related to infrastructure ...
Models that Grossberg introduced and helped to develop include: the foundations of neural network research: competitive learning, self-organizing maps, instars, and masking fields (for classification), outstars (for spatial pattern learning), avalanches (for serial order learning and performance), gated dipoles (for opponent processing);