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100289462 n/a Ensembl ENSG00000177257 ENSG00000275444 ENSG00000285433 n/a UniProt O15263 n/a RefSeq (mRNA) NM_001205266 n/a RefSeq (protein) NP_001192195 NP_004933 n/a Location (UCSC) Chr 8: 7.41 – 7.42 Mb n/a PubMed search n/a Wikidata View/Edit Human Beta-defensin 2 (BD-2) also known as skin-antimicrobial peptide 1 (SAP1) is a peptide that in humans is encoded by the DEFB4 (defensin, beta ...
In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs (e.g. the epidermis, bronchial tree and genitourinary tract). Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and ...
[25] [26] Human defensins have been thought to act through a similar mechanism, targeting cell membrane lipids as part of their function. In fact human beta-defensin 2 have now been shown to kill the pathogenic fungi Candida albicans through interactions with specific phospholipids. [ 27 ]
The human genome contains theta-defensin genes, but they have a premature stop codon, hampering their expression. An artificial human theta-defensin, [40] retrocyclin, was created by 'fixing' the pseudogene, and it was shown to be effective against HIV [41] and other viruses, including herpes simplex virus and influenza A. They act primarily by ...
629114 Ensembl ENSG00000125903 ENSMUSG00000074681 UniProt Q9H1M3 Q30KP0 RefSeq (mRNA) NM_080831 NM_001037933 RefSeq (protein) NP_543021 NP_001033022 Location (UCSC) Chr 20: 0.23 – 0.23 Mb Chr 2: 152.3 – 152.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene. Defensins are cysteine -rich cationic ...
Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans. [5] [6] [7] Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin ...
n/a Ensembl ENSG00000186579 ENSG00000285617 n/a UniProt Q8N104 n/a RefSeq (mRNA) NM_152251 n/a RefSeq (protein) NP_689464 n/a Location (UCSC) Chr 8: 7.83 – 7.83 Mb n/a PubMed search n/a Wikidata View/Edit Human Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short ...
In prokaryotes, the release factors are characterized in 2 classes. Class 1 release factors recognize stop codon, and class 2 release factors stimulate hydrolysis by GTPase activity. However, prokaryotes don't have a single protein to recognize all the stop codons. The stop codon UAG is decoded by Release Factor 1 (RF1) and UGA is decoded by ...