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Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [ 1 ]
The company produces and sells a variety of medicines, with 1,400 approved therapeutic molecules in its portfolio. [31] It owns brands (like Viagra , Xanax , Lipitor ), [ 6 ] [ 32 ] generics , including branded and complex generics, biosimilars , [ 33 ] [ 34 ] and over-the-counter (OTC) drugs and active pharmaceutical ingredients .
Although atorvastatin was the fifth statin to be developed, clinical trials showed that atorvastatin caused a more dramatic reduction in low-density lipoprotein pattern C (LDL-C) than the other statin drugs. Upon its patent expiration in 2011, Lipitor was the best-selling drug ever, with approximately $125 billion in sales over 14.5 years. [23]
Jb Reed, Bloomberg via Getty Images By Emily Jane Fox CVS (CVS) charges $150 for a monthly prescription of the generic version of the cholesterol drug Lipitor. The same drug goes for $17 at Costco.
Cholesterol drugs Zetia and Vytorin together accounted for 10% of Merck's pharma sales last year. But while Zetia managed to recover from a sales plunge, the duo's end is still in sight. Big fall
In 2027, negotiated prices will go into effect for 15 more drugs, followed by another 15 drugs in 2028 and 20 more in each subsequent year should the program remain in place.