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Accordingly, nonselective beta blockers are expected to have antihypertensive effects. [72] The primary antihypertensive mechanism of beta blockers is unclear, but may involve reduction in cardiac output (due to negative chronotropic and inotropic effects). [73]
Types of beta blockers. The Cleveland Clinic classified beta blockers into two categories, cardioselective and nonselective, according to its website. The latter is for medicines that block the B1 ...
Propranolol is a non-selective β-adrenergic receptor antagonist, or beta blocker; [61] that is, it blocks the action of epinephrine (adrenaline) and norepinephrine (noradrenaline) at both β 1-and β 2-adrenergic receptors.
β-blockers can be selective for either β 1, β 2 adrenergic receptor, or to be non-selective. By blocking β 1 receptor it is possible to reduce heart rate, conduction of velocity and contractility. The blocking of β 2 receptor promotes vascular smooth muscle contraction, which results in increase of peripheral resistance. [13]
Carvedilol is a nonselective beta blocker and alpha-1 blocker. [5] How it improves outcomes is not entirely clear but may involve dilation of blood vessels. [5] Carvedilol was patented in 1978 and approved for medical use in the United States in 1995. [5] [8] It is on the World Health Organization's List of Essential Medicines. [9]
Nadolol is a non-selective beta blocker; that is, it non-selectively blocks both beta-1 and beta-2 receptors. It has a preference for beta-1 receptors, which are predominantly located in the heart, thereby inhibiting the effects of catecholamines and causing a decrease in heart rate and blood pressure.
ATC code C07 Beta blocking agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Sotalol is a non-selective β-adrenergic receptor blocker which has both class II and class III antiarrhythmic properties. [1] ... As with other beta blockers, ...