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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...
Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other countries, including the UK, Ireland, Australia, Canada, France and Brazil. As of 2008, ondansetron and granisetron are the only 5-HT 3 antagonists available as a generic drug in the United States. Ondansetron may be given ...
Adverse effects include prolongation of the QT interval on electrocardiogram (EKG). Medications include ondansetron, granisetron, and dolasetron. Anticholinergics can be used as a long-acting patch placed behind the patient's ear. Adverse effects include dry mouth and blurry vision.
Aprepitant has also been shown to increase the activity of the 5-HT 3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy. [11] Netupitant has recently been approved by USFDA. It has also been marketed in combination with palonosetron.
After surgery, Smith was prescribed ciprofloxacin, oxycodone, and ondansetron, the medical examiner's department said, adding that she developed a headache after the operation.
Patients do receive antiemetic medications, such as Ondansetron and Dexamethasone, during the surgical procedure if the patient is at risk for it. [1] [6] Along with PONV, there are numerous complications that can happen with many different organ systems, the most threatening of which involves the respiratory system, and cardiovascular system. [5]
Nausea and vomiting may lead to further medical conditions and complications including: dehydration, electrolyte imbalance, malnutrition, and a decrease in quality of life. [3] Nausea may be defined as an unpleasant sensation of the need to vomit. [7] It may be accompanied by symptoms such as salivation, feeling faint, and a fast heart rate. [7]
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