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Cerebrovascular accident (stroke); Myocardial infarction (heart attack); Cardiomyopathy; Congestive heart failure; Bradycardia; Dysphoria; Hallucinations; Feelings of ...
Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating. [10] [12] Serious side effects may include movement disorders, serotonin syndrome, and seizures. [12] Its use in pregnancy appears to be safe but has not been well studied, and use during breastfeeding has not been well studied either. [12] [13]
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
Buspar – an anxiolytic used to treat generalized anxiety disorder; Belbuca, Buprenex, Butrans, Subutex, Probuohine (buprenorphine) - an opioid medicine used to treat moderate to severe pain, and in some formulations to treat opioid use disorder; Belsomra – used to treat insomnia
A common metabolite of several azapirones including buspirone, gepirone, ipsapirone, revospirone, and tandospirone is 1-(2-pyrimidinyl)piperazine (1-PP). [47] [48] [49] 1-PP possesses 5-HT 1A partial agonist and α 2-adrenergic antagonist actions and likely contributes overall mostly to side effects. [47] [48] [50]
more extrapyramidal side effects (EPS) and less antihistaminic effects (e.g. sedation), alpha adrenergic antagonism (e.g. orthostatic hypotension), and anticholinergic effects (e.g. dry mouth) middle: perphenazine and loxapine: intermediate D2 affinity, with more off-target effects than high-potency agents low: chlorpromazine
Side effects of gepirone include dizziness, nausea, insomnia, abdominal pain, and dyspepsia (indigestion). [1] Gepirone acts as a partial agonist of the serotonin 5-HT 1A receptor. [1] [2] An active metabolite of gepirone, 1-(2-pyrimidinyl)piperazine, is an α 2-adrenergic receptor antagonist. [1] [3] Gepirone is a member of the azapirone group ...
Such effects can be useful in managing the effects of serotonergic psychedelics, including clinically in the case of benzodiazepines. [3] [31] While employed by recreational users for harm-reduction purposes, the use of trip killers to abort the effects of psychedelics and other hallucinogens is not fully characterized and could pose medical risks.