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xkcd, sometimes styled XKCD, [‡ 2] is a serial webcomic created in 2005 by American author Randall Munroe. [1] The comic's tagline describes it as "a webcomic of romance, sarcasm, math, and language".
Thing Explainer: Complicated Stuff in Simple Words is a 2015 illustrated non-fiction book created by Randall Munroe, in which the author attempts to explain various complex subjects using only the 1,000 most common English words. Munroe conceptualized the book in 2012, when drawing a schematic of the Saturn V rocket for his webcomic xkcd.
The form comes with two worksheets, one to calculate exemptions, and another to calculate the effects of other income (second job, spouse's job). The bottom number in each worksheet is used to fill out two if the lines in the main W4 form. The main form is filed with the employer, and the worksheets are discarded or held by the employee.
The post The Complicated Ukraine-Russia War, Explained in Simple Terms appeared first on Reader's Digest. As war erupted in Ukraine, many people wondered how things got to this point. Here, we ...
M–Cdk activity promotes the events of early mitosis, resulting in the metaphase alignment of sister chromatids on the spindle. M–Cdk activity also promotes the activation of APCCdc20, which triggers anaphase and mitotic exit by stimulating the destruction of regulatory proteins, such as securin and cyclins, that govern these events.
Cyclin binding alone causes partial activation of Cdks, but complete activation also requires activating phosphorylation by CAK. In animal cells, CAK phosphorylates the Cdk subunit only after cyclin binding, and so the two steps in Cdk activation are usually ordered as shown here, with cyclin binding occurring first.
News of the Supreme Court ruling that affirmative action in higher education is unconstitutional has catapulted the policy that was legal for at least 45 years to the forefront.
Tertiary structure of human Cdk2, determined by X-ray crystallography. Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) that is primarily made up of alpha helices.