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They can be used to help deliver drugs more efficiently to the spinal cord and to support cells, and they can be injected into an injured area to fill a lesion. [2] They can be implanted into a lesion site with drugs or growth factors in them to give the chemicals the best access to the damaged area and to allow sustained release. [2]
CDK is a cell-cycle promoting protein, which along with other pro-growth proteins is abnormally activated during glial scar formation. [citation needed] Such proteins can increase astrocyte proliferation and can also lead to cell death, thus exacerbating cellular damage at the lesion site.
Spinal column injury is trauma that causes fracture of the bone or instability of the ligaments in the spine; this can coexist with or cause injury to the spinal cord, but each injury can occur without the other. [23] Abnormalities might show up on magnetic resonance imaging (MRI), but the term was coined before MRI was in common use. [24]
The proximal segment can either die by apoptosis or undergo the chromatolytic reaction, which is an attempt at repair. In the CNS, synaptic stripping occurs as glial foot processes invade the dead synapse. [1] Nervous system injuries affect over 90,000 people every year. [2] Spinal cord injuries alone affect an estimated 10,000 people each year ...
Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.
The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis . Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made.
The injured spinal cord is an “altered” spinal cord. After a SCI, supraspinal and spinal sources of control of movement differ substantially from that which existed prior to the injury, [20] thus resulting in an altered spinal cord. The automaticity of posture and locomotion emerge from the interactions between peripheral nervous system ...
Micrograph showing gliosis in the cerebellum. Reactive astrocytes on the left display severe proliferation and domain overlap. Reactive astrogliosis is the most common form of gliosis and involves the proliferation of astrocytes, a type of glial cell responsible for maintaining extracellular ion and neurotransmitter concentrations, modulating synapse function, and forming the blood–brain ...