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Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [ 3 ] [ 4 ] Generally it is used together with dietary changes and a statin . [ 5 ]
The minimum lethal dose in dogs is over 5 mg/m 2; dogs have tolerated getting ten times the standard dose. [9] [33] Signs of overdose include panting, trembling, vomiting, and diarrhea, as well as increased blood levels of creatine kinase, aspartate transaminase, and alanine transaminase. Dogs who received atipamezole without first receiving ...
With median follow-up of 6 years, simvastatin+ezetimibe was found to reduce the primary outcome of CV mortality, major CV event, or nonfatal stroke (34.7% vs. 32.7%; P=0.016; NNT 50 per 7 years or NNT 350 per 1 year ). There was no reduction in all-cause or CV mortality with simvastatin+ezetimibe, though there was a reduction in MI and stroke. [6]
No seizures were seen within 16 hours of acepromazine administration in the 36 dogs that received the drug, and the seizures abated for 1.5 to 8 hours (n=6) or did not recur (n=2) in eight of 10 dogs that were actively seizing. Excitement-induced seizures were reduced for 2 months in one dog. [17]
[5] [10] Subcutaneously administered maropitant had peak plasma concentration around half an hour after administration; the mean half-life is 6–8 hours, and a single dose lasts 24 hours in dogs. [10] Orally administered maropitant reached its peak plasma concentration within two hours. [12]
Studies in animals such as horses have shown the presence of grapiprant in serum 72 hours with a concentration >0.005 ng/mL after the initial administration of a dose of 2 mg/kg. Grapiprant is expeditiously absorbed and the reported serum concentration was reported to be 31.9 ng/ml in an amount of time of 1.5 hours.
Say you have a 4-year-old Labrador named Comet — with the new equation, Comet's real "dog age" would be slightly older than 53. The reason for the difference is actually pretty simple.
[6] Tepoxalin can only be administered to dogs that weigh 3 pounds (1.4 kg) or larger at a dose of 10–20 mg/kg at a daily schedule. [7] The approximate duration of complete treatment is at most 14 days. [1] If treated for a prolonged period of time (more than 180 days), it may result in gastrointestinal irritation and gastric ulceration.