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  2. SGLT2 inhibitor - Wikipedia

    en.wikipedia.org/wiki/SGLT2_inhibitor

    Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...

  3. Sodium-glucose transport proteins - Wikipedia

    en.wikipedia.org/wiki/Sodium-glucose_transport...

    SGLT2 inhibitors, also called gliflozins, [14] are used in the treatment of type 2 diabetes. SGLT2 is only found in kidney tubules and in conjunction with SGLT1 resorbs glucose into the blood from the forming urine. By inhibiting SGLT2, and not targeting SGLT1, glucose is excreted which in turn lowers blood glucose levels. Examples include ...

  4. Discovery and development of gliflozins - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Because sodium is absorbed at the same time as glucose via SGLT-2, the upregulation of SGLT-2 probably leads to development or maintenance of hypertension. In study where rats were given either ramipril or losartan, levels of SGLT-2 protein and mRNA were significantly reduced. In patients with diabetes, hypertension is a common problem so this ...

  5. Calorie restriction plus common diabetes drug leads to higher ...

    www.aol.com/calorie-restriction-plus-common...

    A new study has found a combination of an SGLT-2 inhibitor drug and a moderately calorie-restrictive diet provides higher rates of type 2 diabetes remission compared to just calorie restriction alone.

  6. A diabetes drug may help prevent dementia, new research shows

    www.aol.com/diabetes-drug-may-help-prevent...

    What are SGLT-2 inhibitors? SGLT-2 inhibitors are relatively new drugs that treat type 2 diabetes. The first SGLT-2 inhibitor approved for use in the United States was dapagliflozin (Farxiga), in ...

  7. Sodium/glucose cotransporter 2 - Wikipedia

    en.wikipedia.org/wiki/Sodium/glucose_cotransporter_2

    SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. [6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus. [7]