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Minnich et al. dosed mongrel dogs subcutaneously with aminopterin and folic acid simultaneously to test whether folic acid can rescue animals from the lethality and toxicity of aminopterin [24] Dogs were given 0.020, 0.046, 0.044 escalated to 0.088, and 0.097 mg/kg aminopterin each day for 7 to 12 days. Folic acid was given in a weight ratio to ...
The Rhodesian Ridgeback is a large dog breed originally bred in Southern Africa. [1] The original breed standard was drafted by F.R. Barnes, in Bulawayo, Southern Rhodesia (now Zimbabwe), in 1922, and approved by the South African Kennel Union in 1927. Its forebears can be traced to the ridged hunting and guardian dogs of the Khoikhoi.
Folate targeting is a method utilized in biotechnology for drug delivery purposes. This Trojan Horse process, which was created by Drs. Christopher P. Leamon and Philip S. Low, involves the attachment of the vitamin, folate (), to a molecule/drug to form a "folate conjugate". [1]
The un-methylated form, folic acid (vitamin B 9), is a synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase to become biologically active. [1] It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate.
Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. [3] [10] NTDs include anencephaly and spina bifida, among other defects.
New Hampshire lawmakers state in House Bill 1102 that birth defects and deformities like brachycephaly, or intentional breeding of animals with these defects, causes hardships in dogs' lives.
Dogs commonly give birth in a whelping box, a simple box or pen provided to the dam to help shelter and contain the puppies. A person who intentionally mates dogs to produce puppies is referred to as a dog breeder. Line breeding is the planned breeding of dogs with their relatives. This is done to strengthen the appearance of specific desired ...
Methotrexate also indirectly inhibits purine synthesis by blocking the metabolism of folic acid (it is an inhibitor of the dihydrofolate reductase). Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase and, thus, lowers the level of uric acid in the body. This may be useful in the treatment of gout, which is a disease caused ...