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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Alcohol-induced asthma reactions among Asians has been most thoroughly studied in those of native Japanese descent. In such individuals, the ingestion of virtually any alcoholic beverage or pure ethanol and, in some cases, the smelling of ethanol fumes may be followed, typically within 1–30 minutes, by one or more of the following symptoms: an alcohol flush reaction (i.e. the "Asian flush ...
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [2] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy. [3]
As cancer has been linked to alcohol use, per the surgeon general's new advisory, addiction experts offer helpful tips to cut back on drinking in a safe, healthy way.
Generally, men should be seeking 1.6 grams a day of fish oil for adequate omega-3 essential nutrients — though a deficient person may be advised otherwise. For the record, most people in the U.S ...
For reference, experts recommend no more than one drink a day for females and no more than two drinks a day for males. One drink is defined as 1.5 ounces of liquor, 12 ounces of beer or 5 ounces ...
Alcohol is also converted into phosphatidylethanol (PEth, an unnatural lipid metabolite) by phospholipase D2. This metabolite competes with PIP 2 agonist sites on lipid-gated ion channels. [28] [29] The result of these direct effects is a wave of further indirect effects involving a variety of other neurotransmitter and neuropeptide systems. [25]
A study featured in the journal Food and Function indicated that consuming half of a fresh medium Hass avocado alongside a burger, instead of just the burger by itself, may reduce the generation ...