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The Immune System (Peter Parham), Molecular Driving Forces (Ken A. Dill & Sarina Bromberg), and Physical Biology of the Cell (Rob Phillips, Jane Kondev & Julie Theriot). As of 2018, [update] the Garland Science website had been shut down and their major textbooks have been sold to W. W. Norton & Company .
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as cancer cells, parasitic worms, and also objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major ...
MHC class I molecules bind peptides that are predominantly 8-10 amino acid in length (Parham 87), but the binding of longer peptides have also been reported. [ 6 ] While a high-affinity peptide and the B2M subunit are normally required to maintain a stable ternary complex between the peptide, MHC I, and B2M, under subphysiological temperatures ...
In academia, computational immunology is a field of science that encompasses high-throughput genomic and bioinformatics approaches to immunology.The field's main aim is to convert immunological data into computational problems, solve these problems using mathematical and computational approaches and then convert these results into immunologically meaningful interpretations.
Parham, Peter, The Immune System 3rd ed. (2009) Garland Science: London and New York Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (July 1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing" .
Traditional thinking was that the immune system identified infections directly but this discovery turned that theory on its head. Compatibility genes were essential in immune system mediated viral clearing. The pair coined the term "MHC Restriction" to describe this relationship between T-cells, specific MHC proteins, and viral detection. [1]
English: Collective defences (pale grey, dotted line) of a group comprises all individual defences (elipse) of the group members and their interaction (arrows). Individual defences are composed of anti-parasite behaviours (B, dark grey) and physiological immune systems that can contain either only the innate (I) immune component (e.g. invertebrates) or also the acquired (A) immune component (e ...
The following outline is provided as an overview of and topical guide to immunology: . Immunology – study of all aspects of the immune system in all organisms. [1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency ...