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Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. Examples of sympathomimetic effects include increases in heart rate , force of cardiac contraction , and blood pressure . [ 1 ]
Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant. [9] [1] [10] [11] It was once common in prescription and over-the-counter cough and cold preparations. The medication is taken orally. [4] [12] Side effects of phenylpropanolamine include increased heart rate and ...
Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter complications were caused by the fenfluramine component of the "fen-phen" combination. [3] Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant ...
Side effects of mephentermine include dry mouth, sedation, reflex bradycardia, arrhythmias, and hypertension. [4] Mephentermine induces the release of norepinephrine and dopamine and is described as an indirectly acting sympathomimetic and psychostimulant . [ 4 ]
Sympatholytic drugs produce an opposing effect to sympathomimetic drugs. They reduce or inhibit sympathetic nervous system action. The mode of action of sympatholytic drugs includes the direct mode of blocking the activation of adrenoreceptors by receptor antagonist (blocker), and the indirect mode of inhibiting noradrenaline synthesis, storage ...
Norepinephrine is used mainly as a sympathomimetic drug to treat people in vasodilatory shock states such as septic shock and neurogenic shock, while showing fewer adverse side-effects compared to dopamine treatment. [5] [6]
Ephedrine is a non-catecholamine sympathomimetic with cardiovascular effects similar to those of adrenaline/epinephrine: increased blood pressure, heart rate, and contractility. Like pseudoephedrine it is a bronchodilator , with pseudoephedrine having considerably less effect.
Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the 1980s.