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Use of chondroitin in routine clinical practice should therefore be discouraged." Also in 2007, Bruyere et al. [45] without using explicit methodology for reviewing trials concluded "there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA." The effectiveness of glucosamine is controversial.
Paradigm's IND application to commence its phase 3 pivotal clinical trial investigating Pentosan Polysulphate Sodium (PPS) for the treatment of pain associated with knee osteoarthritis has been cleared by the US FDA. Approximately 65 sites have been identified throughout the US and Australia. Contracting with many of those sites has been completed.
Non-operative treatment vs. hip replacement surgery for osteoarthritis of the hip (English) Painkillers vs. joint injections vs. knee replacement surgery for managing knee pain and activity level in osteoarthritis of the knee (English) Lifestyle and weight loss vs. medication for self-management of osteoarthritis of the knee (English and Spanish)
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population as of 2015. [4] [12] It becomes more common as people age. [1] Among those over 60 years old, about 10% of males and 18% of females are affected. [2] Osteoarthritis is the cause of about 2% of years lived with disability. [12]
The US Centers for Disease Control recommended that physical therapy and exercise be prescribed as first-line treatments (rather than opioids) for multiple causes of chronic pain in 2016 guidelines. [10] Applicable disorders include chronic low back pain, osteoarthritis of the hip and knee, and fibromyalgia. [10]
There is no evidence to support the use of ultrasound for the treatment of low back pain, [24] and current clinical guidelines recommend that ultrasound is not used for this condition. [25] In a critical review, it was demonstrated that therapeutic ultrasound was effective in improving pain, function, and cartilage repair in knee osteoarthritis.