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Eplerenone, sold under the brand name Inspra, is an aldosterone antagonist type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for people with resistant hypertension due to elevated aldosterone.
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Structural formula of the potassium-sparing diuretics. Click to enlarge. Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3]
A drug class is a group of medications and other compounds that share similar chemical structures, act through the same mechanism of action (i.e., binding to the same biological target), have similar modes of action, and/or are used to treat similar diseases. [1] [2] The FDA has long worked to classify and license new medications.
2-Methoxynaphthalene, also called β-naphthol methyl ether or yara yara, [2] is a stabilizer found in gunpowder, particularly smokeless gunpowders.It is soluble in alcohol, and insoluble in water and dipropylene glycol.
A newer medication, eplerenone, has been approved by the US Food and Drug Administration (FDA) for the treatment of heart failure, and lacks the antiandrogenic effects of spironolactone. As such, it is far more suitable for men for whom long-term medication is being chosen.
Chemical formula Synonyms CAS number CAgO carbonylsilver: CCl 2 F 2: dichlorodifluoromethane freon-12: 75-71-8 CCl 4: carbon tetrachloride tetrachloromethane: 56-23-5 C(CN) 4: tetracyanomethane: 24331-09-7 CFCl 3: trichlorofluoromethane freon-11: 75-69-4 CFCl 2 CF 2 Cl: chlorotrifluoromethane freon-13: 75-72-9 CHCl 3: chloroform ...
This mechanism, which runs from renin through Ang II and to aldosterone, as well as the negative feedback that Ang II has on renin secretion, is known as RAAS. [23] The net effect is to increase blood pressure, which in normal physiology is necessary in order to maintain homeostasis .