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"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic , sedative , hypnotic , skeletal muscle relaxant , amnesic , and anticonvulsant effects.
Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. [14] It is used to treat anxiety (including anxiety disorders ), trouble sleeping , severe agitation , active seizures including status epilepticus , alcohol withdrawal , and chemotherapy-induced nausea and vomiting . [ 14 ]
With most benzodiazepines, noticeable effects usually wear off within a few hours. Nevertheless, as long as the drug is present it will exert subtle effects within the body. These effects may become apparent during continued use or may appear as withdrawal symptoms when dosage is reduced or the drug is stopped.
Used off-label to treat insomnia; Sonata – a non-benzodiazepine hypnotic; Spravato – a rapid-acting antidepressant of the NMDA receptor antagonist class; enantiomer of ketamine; Stelazine (trifluoperazine) – an antipsychotic used in the treatment of psychotic disorders, anxiety, and nausea caused by chemotherapy [2]
The reason it took 24 weeks for improvements to be seen after cessation of benzodiazepine use was due to the time it takes the brain to adapt to the benzodiazepine-free environment. [ 136 ] At 24 weeks, significant improvements were found, including accuracy of information processing improved, but a decline was seen in those who remained on ...
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Opinion as to the time needed to complete withdrawal ranges from four weeks to several years. A goal of less than six months has been suggested, [ 12 ] but due to factors such as dosage and type of benzodiazepine, reasons for prescription, lifestyle, personality, environmental stresses , and amount of available support, a year or more may be ...