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Macrophages at the implant site fuse to form foreign body giant cells. [6] Following the inflammatory response, granulation tissue form. The end stage of the foreign body reaction is the fibrous capsule formation around the implanted biomaterial. [6] The biocompatibility of the device affects the severity of the foreign body reaction. [7]
Foreign body giant cells are involved in the foreign body reaction, phagocytosis, and subsequent degradation of biomaterials which may lead to failure of the implanted material. [4] When produced, the FBGC's place themselves along the surface of the implantation, and will remain there for as long as the foreign material remains in the body. [1]
Orthopedic implant example seen with X-ray. An orthopedic implant is a medical device manufactured to replace a missing joint or bone, or to support a damaged bone. [1] The medical implant is mainly fabricated using stainless steel and titanium alloys for strength and the plastic coating that is done on it acts as an artificial cartilage. [2]
In order to remove the bacteria, the implant would have to be removed. Lastly, the immune system may accept the presence of the implant and repair and remodel the surrounding tissue. Similar responses occur when the body initiates an allergic foreign body response. In the case of an allergic foreign body response, the implant would have to be ...
Mesh implantation will naturally generate an inflammatory response to the inserted mesh, but biocompatibility ranges from how easily it is integrated to how severe the foreign body reaction is. A minimal response includes the formation of fibrosis around the prosthesis (much like in scar tissue formation); this response is generated with the ...
Joint replacement surgery is often indicated from various joint diseases, including osteoarthritis and rheumatoid arthritis. [citation needed] Joint replacement has become more common, mostly with knee and hip replacements. About 773,000 Americans had a hip or knee replaced in 2009. [1]
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Knee replacement, also known as knee arthroplasty, is a surgical procedure to replace the weight-bearing surfaces of the knee joint to relieve pain and disability, most commonly offered when joint pain is not diminished by conservative sources.