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Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike acetylcholine , bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.
A parasympathomimetic drug, sometimes called a cholinomimetic drug [1] or cholinergic receptor stimulating agent, [2] is a substance that stimulates the parasympathetic nervous system (PSNS).
Effects of anticholinergic drugs include: Delirium (often with hallucinations and delusions indistinguishable from reality); Ocular symptoms (from eye drops): mydriasis, pupil dilation, and acute angle-closure glaucoma in those with shallow anterior chamber [11] [12] [13]
Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease.
"Anti-cholinergic" side-effects, including urinary hesitancy/retention, may be treated/reversed with bethanechol and/or other acetylcholine-agonists. [48] [49] [50] Bethanechol may also be able to alleviate the sexual-dysfunction symptoms which may occur in the context of tricyclic-antidepressant treatment. [51] [52] [53]
Triethylenetetramine (TETA and trien), also known as trientine when used medically, is an organic compound with the formula [CH 2 NHCH 2 CH 2 NH 2] 2.The pure free base is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air oxidation.
The stereochemistry of pyridine nitrogen and/or the pyridine ring, qua stereoelectronic effects, show positive, albeit subtle effects on binding to α4β2 nAChR. A pyridyl ether ligand with a bromo-substituted pyridine, and metylatedamide-subtituted amino group exhibited the highest potency.
Hyoscine butylbromide, also known as scopolamine butylbromide [4] and sold under the brandname Buscopan among others, [5] is an anticholinergic medication used to treat abdominal pain, esophageal spasms, bladder spasms, biliary colic, [6] and renal colic.