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AFP can be fractionated by affinity electrophoresis into three glycoforms: L1, L2, and L3 based on the reactivity with the lectin Lens culinaris agglutinin (LCA). AFP-L3 binds strongly to LCA via an additional α 1-6 fucose residue attached at the reducing terminus of N-acetylglucosamine; this is in contrast to the L1 isoform.
A lectin from Ulex europaeus is used to identify the H blood group antigen. A lectin from Vicia graminea is used to identify the N blood group antigen. A lectin from Iberis amara is used to identify the M blood group antigen. Non blood-group antigens can be identified by lectins: A lectin from coconut milk is used to identify Theros antigen.
CLEC10A is the only C-type lectin within the human immune system that exclusively recognizes terminal GalNAc. [9] This includes the Tn antigen (GalNAc O-bound to serine or threonine) which is prominently expressed on carcinomas, where it can also be sialylated. These tumor-associated antigens (Neu5Acα2,6-Tn, and NeuGcα2,6-Tn) are also bound. [10]
17195 Ensembl ENSG00000165471 ENSMUSG00000024863 UniProt P11226 P41317 RefSeq (mRNA) NM_000242 NM_001378373 NM_001378374 NM_010776 NM_001365058 RefSeq (protein) NP_000233 NP_001365302 NP_001365303 NP_034906 NP_001351987 Location (UCSC) Chr 10: 52.77 – 52.77 Mb Chr 19: 30.21 – 30.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mannose-binding lectin (MBL), also called mannan ...
Having a super-sensitive multi-cancer screening tool that could actually save lives is the ... For about 1% of those ages 50 to 79, test results will show a cancer signal was detected, along with ...
Structure of mannose in its α-D mannopyranose form. Mannan is a polymer of mannose.. The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated complement proteins further down the cascade.
According to the Centers for Disease Control and Prevention (CDC), women over 50 are at a higher risk for osteoarthritis. This age is around the time that menopause happens .
A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. [3] The C-type designation is from their requirement for calcium for binding. [4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.
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