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His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy. [ 10 ] Wilder's colleague, paediatrician Mynie Gustav Peterman , later formulated the classic diet, with a ratio of one gram of protein per kilogram of body weight in children, 10–15 g of carbohydrate per day, and the remainder of ...
This discovery sparked the introduction of the MCT-ketogenic diet, a modification of the ketogenic diet. In the MCT-ketogenic diet, MCT oil is added to ketogenic meals, [35] which allows the carbohydrate content to be increased. The efficacy of the MCT ketogenic diet does not differ significantly from the classic ketogenic diet; however, not ...
Russell Morse Wilder Sr. (November 24, 1885 – December 16, 1959) [1] was an American physician, diabetologist, epileptologist, and medical researcher, known as one of the originators of the ketogenic ("classic keto") diet as a therapy for both epilepsy [2] [3] and diabetes. [4] [5] He coined the term "ketogenic diet."
Ketogenic diets are used to treat epilepsy in children, where there is some evidence it has a positive effect in reducing seizures. [13] There is some evidence that adults too may experience seizure reduction derived from therapeutic ketogenic diets, and that a less strict regimen, such as a modified Atkins diet, is similarly effective.
A 2022 systematic review of the literature has found some evidence to support that a ketogenic diet or modified Atkins diet can be helpful in the treatment of epilepsy in some infants. [168] These types of diets may be beneficial for children with drug-resistant epilepsy; the use for adults remains uncertain. [6]
Physiological ketosis is the non-pathological (normal functioning) elevation of ketone bodies that can result from any state of increased fatty acid oxidation including fasting, prolonged exercise, or very low-carbohydrate diets such as the ketogenic diet. [5] In physiological ketosis, serum ketone levels generally remain below 3 mM. [1]
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Ketogenesis pathway. The three ketone bodies (acetoacetate, acetone, and beta-hydroxy-butyrate) are marked within orange boxes. Ketogenesis is the biochemical process through which organisms produce ketone bodies by breaking down fatty acids and ketogenic amino acids.